Guide

GLP-1 dosing & titration guide

Every GLP-1 peptide shares one rule: start low, go slow. This guide explains why titration matters and how to estimate how long a given amount of peptide lasts.

Why titration?

GLP-1 compounds are titrated — the dose is stepped up over several weeks rather than starting at maintenance. In research, slow titration is associated with better tolerability. Jumping to a high dose is the most common mistake.

Typical research ladders

As a rough reference, semaglutide ladders from ~0.25 mg toward ~2.4 mg weekly; tirzepatide from ~2.5 mg toward ~15 mg; and retatrutide from ~2 mg toward ~12 mg. Each step typically holds for about four weeks before increasing.

How long will a pen last?

That depends on your dose and the cartridge size. Our dose-duration calculator walks the exact titration ladder for your compound and tells you how many weeks a cartridge covers and when to reorder — the same logic our managed service uses to auto-ship refills.

Why the COA still matters

Titration math only works if the milligrams on the label are real. Every batch we ship is third-party tested; verify a batch by its COA before you rely on a dose.

For research use only. Not for human consumption. This is not medical advice — consult a licensed clinician for health decisions.